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About Prilosec OTC® 

Proven 24-Hour Heartburn Protection

With one Prilosec OTC pill a day, you can block frequent heartburn symptoms before they strike for a full 24 hours of heartburn relief. That way you can power on with your day—and rest at night—without concern that your frequent heartburn will flare up. That’s because Prilosec OTC fights heartburn day and night by shutting down many of the acid pumps in your stomach. It’s the all-day, all-night heartburn protection you need.*

How and Why It Works

Watch a short demo illustrating how Prilosec OTC works to dominate heartburn and provide relief. Click here

Product Safety Record

See our historical safety record and learn how to use Prilosec OTC properly to treat frequent heartburn. Click here

Ratings and Reviews

See what other people who take Prilosec OTC have to say, and write your own review.  Click here

From Prescription to OTC

The first prescription proton pump inhibitor (PPI) became the first available over the counter. Click here

Get a Free Sample

Start blocking heartburn before it begins.* 

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* It’s possible while taking Prilosec OTC®. Use as directed for 14 days for treating frequent heartburn.

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