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Taking 1 pill each morning provides long-lasting relief,
so you can get through your days and rest at night*
Heartburn happens when stomach acid refluxes, or flows up, into the esophagus. Frequent heartburn is when you experience heartburn 2 or more times a week.
Prilosec OTC’s active ingredient is omeprazole, a proton pump inhibitor (PPI), that prevents excess acid by reducing the acid production in your stomach. Prilosec OTC starts working on Day 1*.

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Why Choose Prilosec OTC

Prilosec OTC was the first over-the-counter PPI on the market and continues to provide heartburn relief to frequent heartburn sufferers with its trusted formula. It has been the #1 Doctor and Gastroenterologist recommended heartburn medicine for 15 straight years.^ Join more than 30 million heartburn sufferers that have tried Prilosec OTC for their heartburn.**

Its long-lasting formula provides heartburn relief for 24 hours by preventing the excess acid from refluxing up into the esophagus. In comparison to other heartburn medicines, acid controllers (H2s) provide heartburn relief for up to 12 hours, while antacids provide heartburn relief for 1-3 hours.
Why Prilosec OTC Prilosec OTC is the #1 Doctor† Recommended frequent heartburn brand for 14 straight years.SEE WHY