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Prilosec OTC Directions and Dosage

Drug Facts


Active Ingredient (in each tablet)

Omeprazole delayed-release tablet 20 mg (equivalent to 20.6 mg omeprazole magnesium).


Acid reducer


•   Treats frequent heartburn (occurs 2 or more days a week)

•   Not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect            

How to Open Prilosec OTC Package

Getting the pills out of the package is simple.

Just follow these three easy steps to opening your Prilosec OTC package:

  • STEP 1: Open one end of cardboard box and remove pill sleeve.

  • STEP 2: Hold pill sleeve in both hands, foil side up. Place thumbs on single pouch.

  • STEP 3: Apply equal pressure with thumbs, pushing pill through printed side.

Prilosec OTC Directions:

  • For adults 18 years of age and older.

  • This product is to be used once a day (every 24 hours), every day for 14 days.

  • It may take 1 to 4 days for full effect; some people get complete relief of symptoms within 24 hours.

Prilosec OTC 14-Day Course of Treatments

  • Swallow 1 tablet with a glass of water before eating in the morning.

  • Take every day for 14 days.

  • Do not take more than 1 tablet a day.

  • Do not use for more than 14 days unless directed by your doctor.

  • Swallow whole. Do not chew, crush or suck tablets.

Repeat 14-Day Courses (if needed):

  • You may repeat a 14-day course every 4 months.

  • Do not take for more than 14 days or more often than every 4 months unless directed by a doctor.

  • Children under 18 years of age: ask a doctor. Heartburn in children may sometimes be caused by a serious condition.