How Prilosec OTC Works To Block Frequent Heartburn?

Frequent heartburn sufferers know the burning sensation in the chest all too well, especially after a particularly spicy meal or a second cup of coffee as a mid-afternoon pick-me up. Heartburn is uncomfortable, and once it starts, you want relief. The good news: You can tackle the discomfort from frequent heartburn with Prilosec OTC. Prilosec OTC can block heartburn, providing relief all day and all night, with one pill in the morning.*

How Prilosec OTC Works

When you eat, millions of tiny pumps in your stomach lining create acid to break down food. Normally, your lower esophageal sphincter (LES) opens and closes to let food pass from your esophagus into your stomach. When your LES relaxes, excess acids can flow up, or reflux, into your esophagus. This can create the painful, burning sensation of heartburn.

Prilosec OTC works by preventing the excess acid production that can cause heartburn.* Its unique delayed-release formula helps it pass through tough stomach acids. With Prilosec OTC, you can block the acid that causes frequent heartburn for 24 hours with one pill in the morning.*

How to Take Prilosec OTC

Prilosec OTC should be taken once in the morning for up to 14 days, up to three times per year (or every four months). When starting a course, know that it can take 1-4 days for full effect. Some users feel relief as soon as 24 hours after the first pill—but if that’s not the case for you, stay the course and take the entire 14 days of dosing. Prilosec OTC isn’t meant for immediate relief, but one pill in the morning can block heartburn all day and all night.*

If you feel you need Prilosec OTC for any time beyond that, consult with your doctor. You want to make sure you’re not missing a bigger health problem.

Prilosec OTC’s Active Ingredient

Prilosec OTC is a proton pump inhibitor (PPI). The way the active ingredient, omeprazole delayed-release tablet, in Prilosec OTC works to fight heartburn sets it in a whole separate class from other treatments such as histamine blockers or antacids histamine blockers or antacids.

History of Prilosec OTC as a Proven and Trusted Frequent Heartburn Medicine

• 1989: Prilosec is introduced as the first prescription proton pump inhibitor (PPI).
• 2003: Prilosec OTC becomes the first PPI available over-the-counter.
• 2004: Prilosec OTC became the #1-selling heartburn medicine to treat frequent heartburn.‡
• 2005: Prilosec OTC is named the #1 doctor and gastroenterologist-recommended OTC acid reducer…and still is.†^
• 2014: Prilosec OTC has effectively blocked heartburn for over 30 million patient treatments.**

There's a reason over 30 million heartburn sufferers** have tried Prilosec OTC to block frequent heartburn.* Since the beginning, we’ve led the way in OTC frequent heartburn treatments. We were first on the market and have continued to provide relief to frequent heartburn sufferers with our trusted formula. Don’t believe it for yourself? Listen to what Prilosec OTC users say about it.

†IQVIA ProVoiceTM Survey Jan 2005 – Mar 2021.

  • Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill per day as directed to treat frequent heartburn. May take 1 to 4 days for full effect. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Use as directed.

** PG Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16