What is a Proton Pump Inhibitor (PPI)?
Proton pump inhibitors (PPIs) and Acid controllers (H2 receptor blockers) can both help decrease the amount of stomach acid your body produces and decrease symptoms of heartburn. However, there are a few key differences between the two.
PPIs vs H2 Blockers
Unlike antacids, which treat the symptoms of heartburn by simply neutralizing existing acid, acid controllers and PPIs treat the issue at the source, so you don’t feel the effects of stomach acid flowing into your esophagus.
Let’s take a look at the table below how these two types of heartburn medicines are similar and different.
| Acid Controllers/H2 Blockers | Proton Pump Inhibitors (PPIs) |
|---|---|
| Block histamine-2, just one of the several acid-producing stimuli in the stomach | Block acid at the proton pump, making PPIs more effective than H2 blockers at reducing acid production |
| Decreases stomach acid production for 8 hours | Reduce stomach acid for 24 hours, all day and all night |
| Relieve heartburn associated with acid indigestion and sour stomach | Recommended to treat frequent heartburn (heartburn occurring more than twice a week) |
| Begin working in 15-30 minutes | Begin working within 1 hour, full effect in 1 – 4 days |
| Provide relief for up to 12 hours | Provide relief for 24 hours |
| Available over-the-counter | Available over-the-counter |
Can You Take PPIs and H2 Blockers Together for Heartburn Relief?
It is not recommended that you take PPIs and acid controllers at the same time. If you have heartburn that cannot be controlled with a PPI, talk to your doctor about other options to help you find relief.
PPIs Provide Longer-Lasting Relief from heartburn Symptoms
While PPIs and acid controllers both reduce the amount of acid your stomach produces, H2 blockers work more quickly than PPIs, providing relief in as little as 15-30 minutes. PPIs can take longer to kick in, but provide longer-lasting relief, making them ideal for sufferers of frequent heartburn. If you suffer from frequent heartburn (two or more days per week), PPIs like Prilosec OTC can help you find relief*. Prilosec OTC contains the active ingredient omeprazole, while other over-the-counter (OTC) PPIs contain either esomeprazole or lansoprazole. Hear from a Prilosec OTC user on why they decided to try a PPI like Prilosec OTC