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What is a Proton Pump Inhibitor (PPI)?

Proton pump inhibitors (PPIs) and Acid controllers (H2 receptor blockers) can both help decrease the amount of stomach acid your body produces and decrease symptoms of heartburn. However, there are a few key differences between the two.

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^ IQVIA ProVoice Survey, 2005-2025.

†Pharmacy Times 2025-2026 Survey of Pharmacists’ OTC Recommendations

* Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill per day as directed to treat frequent heartburn. May take 1 to 4 days for full effect. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Use as directed.

** PG Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16