PRILOSEC OTC LEGACY
Prilosec OTC is the #1 Doctor and Gastroenterologist recommended brand in the Proton Pump Inhibitors category^. Enjoy your days and nights with Prilosec OTC — your partner in making zero heartburn possible* so you can live the good life!
Doctor Recommended
For over 20 years, Prilosec OTC has been providing a powerful solution for those seeking long-lasting relief*. Originally launched as a prescription medication, Prilosec has been adapted for over-the-counter use, making it accessible to millions who experience the discomfort of frequent heartburn.
What is Prilosec OTC? | Prilosec OTC
Prilosec OTC - your partner in heartburn relief
Every year, countless consumers turn to Prilosec OTC for its reliable and effective relief. With its long-lasting, delayed-release formula, Prilosec OTC provides up to 24 hours of relief with just one pill a day*. It works by reducing the production of stomach acid, blocking heartburn before it starts* so you can live your life without the worrying about unexpected flare-ups.
Prilosec OTC vs Antacids | Prilosec OTC
OUR LEGACYOVER 30 YEARS AGO
1989
OVER 37 YEARS AGO
Launch of Prescription Prilosec: Omeprazole is introduced in the U.S. as a prescription medication under the brand name Prilosec.
1997
OVER 29 YEARS AGO
Strategic Alliance Formed: P&G and AstraZeneca partner to develop and market an over-the-counter version of Prilosec.
2003
OVER 23 YEARS AGO
FDA Approval: The FDA approves Prilosec OTC for sale over-the-counter, allowing consumers to purchase the medication directly.
2003
OVER 23 YEARS AGO
Prilosec OTC Hits Shelves: Prilosec OTC is now available without a prescription and with the tagline "One pill a day, 24 hours, zero heartburn".
2004
OVER 22 YEARS AGO
Road to #1: Prilosec OTC quickly captures market share, becoming the #1 recommended OTC medicine for frequent heartburn.
2005
OVER 21 YEARS AGO
Bunco Championship: Prilosec OTC sponsors the Bunco World Championship, raising heartburn awareness and supporting breast cancer.
2006
OVER 20 YEARS AGO
NFL Sponsorship: Prilosec OTC partners with the NFL for the "Season of a Lifetime" sweepstakes.
2010
OVER 16 YEARS AGO
Madden Most Valuable Protectors Award: Prilosec OTC sponsors the inaugural award, recognizing the NFL's best offensive linemen.
2011
OVER 15 YEARS AGO
Larry the Cable Guy Partnership: Comedian Larry the Cable Guy is announced as the brand's spokesperson.
2012
OVER 14 YEARS AGO
Introduction of Wildberry Flavor: Prilosec OTC launched the first flavored 24-hr frequent heartburn pill for a better experience.
2013
OVER 13 YEARS AGO
Community Engagement: Prilosec OTC engages in initiatives supporting Hispanic communities.
2014
OVER 12 YEARS AGO
Zero Burn Summer Tour: Prilosec OTC launches the "Zero Burn Summer Barbecue Tour," promoting heartburn relief and food enjoyment.
2015
OVER 11 YEARS AGO
Taste of the NFL: Prilosec OTC partners with Taste of the NFL to donate one million meals to food banks across the country.
2021
OVER 5 YEARS AGO
Ongoing Brand Leadership: Prilosec OTC continues to lead the heartburn medication market, prioritizing community engagement.
2025
RECENTLY
Cedric the Entertainer Partnership: Prilosec OTC announces celebrity partnership with Cedric the Entertainer!
^ IQVIA ProVoice Survey, 2005-2025.
†Pharmacy Times 2025-2026 Survey of Pharmacists’ OTC Recommendations
* Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill per day as directed to treat frequent heartburn. May take 1 to 4 days for full effect. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Use as directed.
** PG Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16