IE 10 or 11 may display this page improperly. Please upgrade to Microsoft Edge, Google Chrome, or Firefox.

Acid Controllers vs. PPIs: What’s the Difference?

Acid controllers (H2 receptor blockers) and proton pump inhibitors can both help decrease the amount of stomach acid your body produces. Unlike antacids, which treat the symptoms of heartburn by simply neutralizing existing acid, acid controllers and PPIs treat the issue at the source, so you don’t feel the effects of stomach acid to begin with. There are a few key differences between the two.


It is not recommended that you take PPIs and acid controllers at the same time. If you have heartburn that’s uncontrolled with a PPI, talk to your doctor about options to help you find relief.

In short, while PPIs and acid controllers both reduce the amount of acid your stomach produces, H2 blockers work more quickly than PPI’s, providing relief in as little as 15-30 minutes. PPIs can take longer to kick in, but provide lasting relief, making them ideal for sufferers of frequent heartburn. If you suffer from frequent heartburn (2 or more days per week), PPIs like Prilosec OTC can help you find relief*.

*It’s possible while taking Prilosec OTC®. Use as directed for 14 days to treat frequent heartburn. Do not take for more than 14 days or more often than once every four months unless directed by a doctor. May take 1-4 days for full effect.