How to Take Prilosec OTC

Prilosec OTC should be taken once in the morning for up to 14 days, up to three times per year (or every four months). When starting a course, know that it can take 1-4 days for full effect.

Person in white robe holding a cup in a cozy kitchen setting with Prilosec OTC heartburn medication box on the counter beside an open magazine — morning routine with coffee, reading, and daily acid relief treatment.

How Prilosec OTC Works To Block Frequent Heartburn?

Frequent heartburn sufferers know the burning sensation in the chest all too well, especially after a particularly spicy meal or a second cup of coffee as a mid-afternoon pick-me up. Heartburn is uncomfortable, and once it starts, you want relief.

The good news: You can tackle the discomfort from frequent heartburn with Prilosec OTC. Prilosec OTC can block heartburn, providing relief all day and all night, with one pill in the morning.*

Person sitting on a couch holding a box of Prilosec OTC heartburn medication and text "Use as directed for 14 days to treat frequent heartburn. Do not take for more than 14 days or more often than once every four months unless directed by a doctor".

Person wearing a white lab coat with 'Pharmacist' embroidered on it, set against a purple gradient background includes Prilosec OTC disclaimer text about heartburn treatment duration and usage.

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How Prilosec OTC Works to Block Frequent Heartburn

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^ IQVIA ProVoice Survey, 2005-2025.

†Pharmacy Times 2025-2026 Survey of Pharmacists’ OTC Recommendations

* Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill per day as directed to treat frequent heartburn. May take 1 to 4 days for full effect. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Use as directed.

** PG Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16