How Does Heartburn Occur?

A valve at the bottom of the esophagus, the esophageal sphincter, can open and close to allow food and fluids into the stomach. However, if this sphincter is not working properly, stomach acid can leak back up the esophagus leaving a burning sensation in the chest and throat, also called heartburn. Frequent heartburn is defined as heartburn that occurs two or more days a week.

How are Esomeprazole and Omeprazole Similar?

Esomeprazole and omeprazole share several similarities due to their common class and mechanism of action. Both drugs are highly effective in reducing stomach acid and providing relief from frequent heartburn.

Are Omeprazole and Esomeprazole the Same?

While esomeprazole and omeprazole are similar in many ways, they are not identical. The main difference lies in their slightly different chemical compositions.

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Omeprazole vs. Esomeprazole for Frequent Heartburn

The over-the-counter medicine aisle has so many options to treat different common symptoms. Heartburn is no exception, with two of the most common ingredients for treating frequent heartburn being omeprazole and esomeprazole. In this article, we will delve into the differences and similarities between omeprazole and esomeprazole.

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^ IQVIA ProVoice Survey, 2005-2025.

†Pharmacy Times 2025-2026 Survey of Pharmacists’ OTC Recommendations

* Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill per day as directed to treat frequent heartburn. May take 1 to 4 days for full effect. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Use as directed.

** PG Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16