About Prilosec OTC

How and Why Prilosec OTC Works

When you eat, millions of tiny pumps in your stomach lining create acid to break down food. When your LES (lower esophageal sphincter) relaxes, excess acids can flow up, or reflux, into your esophagus. This can create the painful sensation of heartburn.

Prilosec OTC works by directly blocking many of the active stomach pumps that produce acid before they start. Prilosec OTC is a proton pump inhibitor (PPI). The way the active ingredient in Prilosec OTC works to fight heartburn sets it in a whole separate class from other treatments such as histamine blockers or antacids.

Watch Prilosec OTC in Action

History of Prilosec OTC


Proven and Trusted Frequent Heartburn Medicine


There's a reason over 27 million heartburn sufferers†† have tried Prilosec OTC to block frequent heartburn before it begins.* Since the beginning, we’ve led the way in OTC frequent heartburn treatments. We were first on the market and have continued to provide relief to frequent heartburn sufferers with our trusted formula.

P&G calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel in the US market for Prilosec OTC for the period 8/31/03 through 6/28/14.

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