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Find Your Heartburn Relief: Understanding PPIs, Antacids & H2 Blockers

*Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill per day as directed to treat frequent heartburn. May take 1 to 4 days for full effect. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Use as directed.

Sources:

  1. Proton Pump Inhibitors (PPI). National Library of Medicine. Last updated May 1, 2023. Accessed June 5, 2025.
    https://www.ncbi.nlm.nih.gov/books/NBK557385/
  2. Prilosec OTC (omeprazole) Information. U.S. Food & Drug Administration. Last updated November 27, 2015. Accessed June 5, 2025.
    https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/prilosec-otc-omeprazole-information#:~:text=The%20Food%20and%20Drug%20Administration,counter%20treatment%20for%20frequent%20heartburn
  3. H2 Blockers. National Library of Medicine. Last updated August 11, 2024. Accessed June 5, 2025.
    https://www.ncbi.nlm.nih.gov/books/NBK525994/
  4. Antacids. National Library of Medicine. Last updated August 8, 2023. Accessed June 5, 2025.
    https://www.ncbi.nlm.nih.gov/books/NBK526049/

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^ IQVIA ProVoice Survey, 2005-2025.

†Pharmacy Times 2025-2026 Survey of Pharmacists’ OTC Recommendations

* Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill per day as directed to treat frequent heartburn. May take 1 to 4 days for full effect. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Use as directed.

** PG Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16